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ApoE4, Diet & Lifestyle, The Bredesen Protocol

Alzheimer’s Diet & The Bredesen Protocol

December 29, 2018
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The Bredesen ProtocolTM

Dietition Amylee Amos, of the Amos Institute, chats with Whitney English on an episode of “The Sitch.”  The Amos Institute helps patients with neurodegenerative diseases.  Amylee helps these patients implement a customized  program, called The Bredesen ProtocolTM.  This program was developed by neurologist and neuroscientist, Dr. Dale E. Bredesen after 30 years of research.  This successful program has been proven to prevent and reverse cognitive decline.  Basically, The Bredesen ProtocolTM can help you get your life back!

Alzheimer’s Diet

As a result of testing, the patient follows an individualized  diet.  Mainly, this Alzheimer’s diet is plant based and includes eating healthy fats to promote mild ketosis.  With this intention, a ketone meter can be purchased to check ketone levels.  Chiefly, these healthy fats include coconut oil, nuts (especially walnuts), seeds, avocados, and lean proteins.  Also, low mercury cold water fish can be healthy to eat.  These fish are categorized as “SMASH” – salmon, mackerel, anchovies, sardines, and herring.  Meat should be treated as a condiment and eaten in smaller portions.  In addition, low glycemic fruits can be eaten such as berries.  In particular, blueberries are anti-inflammatory and packed with antioxidants.

Likewise, some foods should be avoided.  Processed foods and even some foods labeled as “healthy,” are not actually healthy.  Also, simple carbohydrates, sugars and artificial sweeteners should be avoided.  Important to note, these artificial sweeteners can harm the microbiome.  Raw honey can be used instead.  Gluten should be eliminated, especially with Alzheimer’s patients.  Specifically, gluten can cause leaky gut and affect the blood brain barrier.

Fasting

A proper diet is important, but when  you eat is also important.  Fasting or time-restricted eating can be done from 12-16 hrs.  This fast begins after supper and 3 hrs. before bedtime.  The longer 16 hr. fast is used by those whose genetic testing reveals they have 1 or 2 copies of the ApoE4 gene.  To clarify, 1 copy of this gene increases risk for Alzheimer’s by 30% and 2 copies by 50-90%.  Also, women with this gene are at even greater risk for Alzheimer’s.  You can test for this gene at home by ordering a kit from 23andme.  As a result of this testing, you will know if you carry 0, 1, or 2 copies of the ApoE4 gene.

Better Brain Health

Better brain health can be achieved by physically exercising 1 hr., 5 times per week.  Your brain needs to be exercised in the same way.  You can challenge your brain with an online computer game available at brainhq.  This brain training program was designed by an international team of neuroscientists after 30 years of research.

Certain vitamins and supplements have been shown to promote brain health.  Fish oil, vitamin D, and CoQ10 are some of these.  However, vitamins and supplements, if not taken in the proper amounts, can have adverse effects.  Consequently, patients should check with their doctors first.

In Conclusion

The same diet and lifestyle strategies can be used to prevent and  reverse Alzheimer’s symptoms.  Alzheimer’s doesn’t have to be a devastating diagnosis anymore.  We now have the information needed to reverse it.

The Amos Institute

The Amos Institute specializes in treating neurodegenerative diseases.  They help patients achieve success using The Bredesen ProtocolTM.  First, they work closely with your doctor, helping you obtain the necessary testing.  Specifically, this testing includes blood testing, genetic testing and diagnostic studies.  Then, The Amos Institute works with you as you follow your customized  program.   More information may be found at amosinstitute.com.

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Glossary


ALZ

abbreviation for Alzheimer’s Disease

Alzheimer’s Disease

a type of dementia and a progressive disease of the brain that slowly causes impairment in memory and cognitive function. Alzheimer’s disease happens when the brain tries to protect itself from three metabolic and toxic threats:

1 - Inflammation (from infection, diet or other causes)

2 - Decline and shortage of supportive nutrients, hormones and other brain-supporting molecules

3 - Toxic substances such as metals or biotoxins (poisons produced by microbes such as molds)


The protective response causes APP (Amyloid Precursor Protein, the long molecule that protrudes from neurons) to be cut into four fragments, including amyloid-beta, that downsize the neural network and eventually destroy synapses and neurons. When the APP molecule is cut into those four pieces, it is not cut into the two pieces that nourish and maintain synapses.

Alzheimer's disease is a state of the brain in which there is an imbalance between the reorganization of synapses that have outlived their usefulness (and which the brain can stand to lose - healthy destruction) and the maintenance or creation of existing and new synapses (which the brain needs to sustain old memories and form new ones, as well as perform other cognitive functions). That imbalance  comes from too many  of the synapse- and neuron-destroying quartet  of molecules snipped from APP and too few  of the synapse- and neuron-sustaining duo  of molecules snipped from APP.


ApoE4

abbreviation for apolipoprotein E, a gene variant (allele) which is a protein that carries lipids – i.e. fats. Carrying one ApoE4 (inherited from one parent) increases your lifetime risk of Alzheimer’s to 30 percent. Carrying two copies (from both parents) increases it to 50 to 90 percent. That compares to a risk of only about 9 percent in those who carry zero copies of this allele.

APP

abbreviation for Amyloid Precursor Protein, the long molecule that protrudes from neurons


Cognoscopy

metabolic and genetic testing that identifies cognitive decline or what may be putting you at risk for it

Dementia

umbrella term for a group of symptoms (a syndrome) without a definitive diagnosis. Dementia is a group of symptoms that affect mental cognitive tasks such as memory and reasoning. (Alzheimer’s Disease is the most common type of dementia.)

Early Alzheimer’s Disease

an early onset of Alzheimer’s Disease and uncommon form of dementia that typically affects those under the age of 65

Functional Medicine

a systems biology–based approach that focuses on identifying and addressing the root cause of disease

Heterozygous

carrying 1 copy of the ApoE4 genetic variant

Homozygous

carrying 2 copies of the ApoE4 genetic variant

Integrative Medicine

healing-oriented medicine that takes account of the whole person, including all aspects of lifestyle. It emphasizes the therapeutic relationship between practitioner and patient, is informed by evidence, and makes use of all appropriate therapies.

Ketoflex 12/3

anti-Alzheimer’s diet to include at least 12 hours of fasting, with the first 3 hours of that fast starting after dinner. It is largely plant based, but flexible as it does allow for small amounts of meat or fish.

MCI

Mild Cognitive Impairment

MCT oil

an abbreviation for medium chain triglyceride (a saturated fat) which is found in coconut oil.  Alzheimer's impairs the brain's ability to use sugar.  An MCT ketogenic diet offers an alternative energy source:  ketones.  This allows brain cells to survive better, blocking a receptor in the brain that causes memory loss.

SCI

Subjective Cognitive Impairment – a precursor to MCI (Mild Cognitive Impairment)

The Bredesen Protocol

treatment program developed by Dr. Dale E. Bredesen to prevent and reverse cognitive decline (also known as The ReCODE ProtocolTM)