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It’s not surprising that two big pharmaceutical companies would recently throw in the towel on testing their highly-touted Alzheimer’s drugs. The silver bullet approach doesn’t work for multi-factored chronic diseases like Alzheimer’s. Instead, the silver buckshot approach is needed to combat the 36 or more causes of Alzheimer’s.

While JAMA, the Journal of the American Medical Association, warns against the “pseudo-medicine” of Alzheimer’s supplements, 21st Century Functional Medicine doctors are seeing reversals of cognitive decline. These doctors are getting to the root causes of chronic diseases such as Alzheimer’s and addressing those causes.

Newly published research proves 100 patients enjoyed significant, measurable symptom reversal using the protocol developed by Dr. Dale Bredesen, making a huge gain over the initial 19 success stories.

Currently, thousands of people practice Dr. Bredesen’s Protocol, which he describes in his book, “The End of Alzheimer’s”.  The treatment involves being tested for three dozen Alzheimer’s risk factors, resulting in an individualized  treatment, which includes lifestyle changes like diet, exercise and fasting.

Dr. Bredesen states that the brain is actually producing amyloid as a protective response  to several different problems. These can be from systemic inflammation, whether from the gut or from infection such as Lyme Disease. This production of amyloid can also be a result of insulin resistance or mold that produces neurotoxins. Joseph Pizzomo’s book, The Toxin Solution: How Hidden Poisons in the Air, Water, Food, and Products We Use Are Destroying Our Health–AND WHAT WE CAN DO TO FIX IT,“  is a great resource and program to follow for those who are combating toxins.

The three main causes of amyloid buildup are the 3 subtypes of Alzheimer’s:

– Chronic inflammation from infections, leaky gut, or poor dentition
– Decrease in nutrients, hormones, or trophic support (growth factors in your brain)
– Toxic substances such as metals, mold, or mercury found in dental work or tuna fish

These are all underlying factors and people typically have more than one – usually between 10 and 25. It’s not enough to tell a patient they have Alzheimer’s. The doctor needs to order the proper tests to determine why  the patient got Alzheimer’s.

When scientists conduct a trial to find a treatment for a particular disease, they want to look at one thing only. But that’s not the way this disease works; this is why so many single drug trials for Alzheimer’s have failed.   The idea of going after something so complex with one drug actually makes no sense.

Dr. Bredesen states that maintaining a healthy gut is critical to avoiding Alzheimer’s and many other chronic illnesses. Many of us suffer from leaky gut and don’t realize it. The best way to prevent inflammatory diseases is through good nutrition. We eat too much in the way of grains, dairy, and the biggest one of all, simple carbohydrates, sugars. These three factors tend to inflame the gut and make it leaky. So the very things you are eating are leaking into your bloodstream. Foods with high fructose corn syrup are causing insulin resistance like Type 2 Diabetes and are increasing the risk for Alzheimer’s.

Instead, a diet that is plant rich with healthy fats like avocados and smaller amounts of meat (pastured chicken and grass fed beef) will be beneficial. It’s important to heal the gut and use probiotics, prebiotics and eat fermented foods like sauerkraut.

There is a cognitive reserve and this reserve can be increased with brain training. We know the brain is neuroplastic (able to change and heal itself) and this neuroplasticity continues throughout our lifetime.

The current scourge is Alzheimer’s just as Leprosy was the scourge in Biblical times and Polio in modern times. This is the beginning of the end of the Alzheimer’s scourge. Dr. Bredesen’s book, The End of Alzheimer’sThe First Program to Prevent and Reverse Cognitive Decline,”  has been translated into 28 languages and shows how this is now possible.

Order this book here.
Order this book here.
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Glossary


ALZ

abbreviation for Alzheimer’s Disease

Alzheimer’s Disease

a type of dementia and a progressive disease of the brain that slowly causes impairment in memory and cognitive function. Alzheimer’s disease happens when the brain tries to protect itself from three metabolic and toxic threats:

1 - Inflammation (from infection, diet or other causes)

2 - Decline and shortage of supportive nutrients, hormones and other brain-supporting molecules

3 - Toxic substances such as metals or biotoxins (poisons produced by microbes such as molds)


The protective response causes APP (Amyloid Precursor Protein, the long molecule that protrudes from neurons) to be cut into four fragments, including amyloid-beta, that downsize the neural network and eventually destroy synapses and neurons. When the APP molecule is cut into those four pieces, it is not cut into the two pieces that nourish and maintain synapses.

Alzheimer's disease is a state of the brain in which there is an imbalance between the reorganization of synapses that have outlived their usefulness (and which the brain can stand to lose - healthy destruction) and the maintenance or creation of existing and new synapses (which the brain needs to sustain old memories and form new ones, as well as perform other cognitive functions). That imbalance  comes from too many  of the synapse- and neuron-destroying quartet  of molecules snipped from APP and too few  of the synapse- and neuron-sustaining duo  of molecules snipped from APP.


ApoE4

abbreviation for apolipoprotein E, a gene variant (allele) which is a protein that carries lipids – i.e. fats. Carrying one ApoE4 (inherited from one parent) increases your lifetime risk of Alzheimer’s to 30 percent. Carrying two copies (from both parents) increases it to 50 to 90 percent. That compares to a risk of only about 9 percent in those who carry zero copies of this allele.

APP

abbreviation for Amyloid Precursor Protein, the long molecule that protrudes from neurons


Cognoscopy

metabolic and genetic testing that identifies cognitive decline or what may be putting you at risk for it

Dementia

umbrella term for a group of symptoms (a syndrome) without a definitive diagnosis. Dementia is a group of symptoms that affect mental cognitive tasks such as memory and reasoning. (Alzheimer’s Disease is the most common type of dementia.)

Early Alzheimer’s Disease

an early onset of Alzheimer’s Disease and uncommon form of dementia that typically affects those under the age of 65

Functional Medicine

a systems biology–based approach that focuses on identifying and addressing the root cause of disease

Heterozygous

carrying 1 copy of the ApoE4 genetic variant

Homozygous

carrying 2 copies of the ApoE4 genetic variant

Integrative Medicine

healing-oriented medicine that takes account of the whole person, including all aspects of lifestyle. It emphasizes the therapeutic relationship between practitioner and patient, is informed by evidence, and makes use of all appropriate therapies.

Ketoflex 12/3

anti-Alzheimer’s diet to include at least 12 hours of fasting, with the first 3 hours of that fast starting after dinner. It is largely plant based, but flexible as it does allow for small amounts of meat or fish.

MCI

Mild Cognitive Impairment

MCT oil

an abbreviation for medium chain triglyceride (a saturated fat) which is found in coconut oil.  Alzheimer's impairs the brain's ability to use sugar.  An MCT ketogenic diet offers an alternative energy source:  ketones.  This allows brain cells to survive better, blocking a receptor in the brain that causes memory loss.

SCI

Subjective Cognitive Impairment – a precursor to MCI (Mild Cognitive Impairment)

The Bredesen Protocol

treatment program developed by Dr. Dale E. Bredesen to prevent and reverse cognitive decline (also known as The ReCODE ProtocolTM)