The End of Alzheimer’s Program

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Basically, Dr. Bredesen’s first book, “The End of Alzheimer’s“, is a roadmap for those who want to reverse or even prevent cognitive decline.  Not only does his book reveal the many causes of Alzheimer’s, but also how those causes can be addressed.  As a result, ALZ symptoms begin to halt and reverse!  Most important, patients need to start with the proper testing, then follow their customized  program to improve cognition.  Thankfully, Dr. Bredesen has developed a “tailor made” program to do just that – The Bredesen ProtocolTM.  So, what is revealed in his second book, “The End of Alzheimer’s Program“?  Let’s take a look …

The End of Alzheimer's Program (2020 book with new findings and more ALZ patient stories) by Dr. Dale E. Bredesen
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“The End of Alzheimer’s Program” by Dr. Dale E. Bredesen

Book Excerpt:

The famous basketball coach, player, and executive Pat Riley exhorted his players to adopt the following attitude when the game is on the line: “Imagine that your head is underwater and you will not be able to breathe again unless you win.” That is some motivation indeed! And it is the attitude we must have about Alzheimer’s disease as well, and in fact about neurodegenerative diseases as a whole— these have all been untreatable terminal illnesses, and if we do not approach them as a societal emergency we will see 13 million demented Americans by 2050, their families destroyed, Medicare bankrupt, and a multi-trillion-dollar global burden of dementia. Yet our “standard of care” is to treat without determining the cause of or contributors to Alzheimer’s, to limit our treatment to a drug or two, to avoid targeted programs of treatment, to refuse clinical trials of multifaceted therapeutics, and to repeat the same old tired, ineffective approaches again and again. Where is the innovation? Where is the inspiration? Perhaps we need a pep talk from Pat Riley?

Therefore, please don’t be concerned if you get your tests, take them to your doctor, and he or she is skeptical. If you ask your doctor to obtain these tests, don’t be surprised if he or she brushes you off with an all-knowing smile or even a look of disdain. As they say, “An expert is someone who does not want to be told anything new in his or her field of expertise.” This personalized approach to cognitive decline is a twenty-first-century approach, not yet in practice by the vast majority of doctors. As one neurologist said, “I wouldn’t order these tests because I would not know how to interpret them.” Another physician said, “These tests don’t tell you whether you have Alzheimer’s or not.” True; what they tell you is why  you have cognitive decline (or risk for decline)—what all of the contributors are. Determining if  you have Alzheimer’s does not help you to avoid it or reverse it; determining why  is the key. Most people who already have Alzheimer’s disease or MCI (mild cognitive impairment, the harbinger of Alzheimer’s) or SCI (subjective cognitive impairment, which precedes MCI) turn out to have between ten and twenty-five contributors, and these are identified by the tests so that each can be addressed therapeutically.

Practitioners have attempted to treat dementia for thousands of years without knowing what caused  it or contributed to it, but now, for the first time, we can actually treat the underlying mechanisms. Of course, when Ayurvedic physicians treated dementia thousands of years ago, they did not refer to it as Alzheimer’s disease—it was not until 1906 and 1907 that Dr. Alois Alzheimer published his famous papers—but Ayurvedic physicians clearly described and attempted to treat dementia, and what we now call Alzheimer’s disease is the most common syndrome of dementia.

Twenty years ago, our laboratory research led us to identify the APP (amyloid precursor protein) switch, and when we began to look at what factors flip this switch toward the Alzheimer’s side—the synaptoclastic side—we found that there are different groups of factors, and thus there are actually different types  of Alzheimer’s disease.

Type 1 Alzheimer’s is inflammatory, or hot, so if you have ongoing inflammation, you are increasing your risk for Alzheimer’s disease. In fact, one of the major mediators of the inflammatory response is called NFκB (nuclear factor kappa-light-chain enhancer of activated B cells), and this increases the production of the very molecular scissors that produce the amyloid from APP, so there really is a direct link from inflammation to Alzheimer’s.

Type 2 Alzheimer’s is atrophic, or cold, so if you have sub-optimal levels of nutrients, hormones, or trophic factors (cell growth factors like NGF, nerve growth factor), you are increasing your risk for Alzheimer’s disease. Simply put, you do not have the support necessary to maintain the five hundred trillion (500,000,000,000,000) synaptic connections in your brain. On the positive side, optimizing those same nutrients, hormones, and trophic factors offers you the best chance for optimizing your memory and overall cognitive function.

Type 1.5 Alzheimer’s is glycotoxic, or sweet, so if you have high blood sugar or high fasting insulin, as 80 million Americans do, you are increasing your risk for Alzheimer’s disease. We call this type 1.5 because it has features of both type 1 and type 2: chronic inflammation (type 1) occurs because the glucose actually attaches to many of your proteins, like remoras to a shark, causing an inflammatory response to these altered proteins (such as hemoglobin A1c, which is hemoglobin with a glucose stuck to it, and hundreds of other proteins). Reduced trophic support (type 2) occurs because your insulin—which is a critical growth factor for your brain cells—has been high chronically, causing your cells to lose their sensitivity to insulin.

Type 3 Alzheimer’s disease is toxic, or vile, so if you have exposure to toxins such as mercury, toluene, or mycotoxins (toxins made by certain molds such as Stachybotrys  and Penicillium), then you are increasing your risk for Alzheimer’s disease. Since we are exposed to hundreds of toxins—from the mercury in seafood and dental amalgams to air pollution to the benzene in paraffin candles to the trichothecenes from the black mold growing in water-damaged homes, and on and on—we all experience this risk to a greater or lesser degree, so the key is to minimize exposure, identify the toxins to which we are exposed, and increase excretion and metabolism of the toxins.

Type 4 Alzheimer’s disease is vascular, or pale, so if you have cardiovascular disease, you are at increased risk for Alzheimer’s disease. Indeed, vascular leakiness represents one of the earliest changes identified in Alzheimer’s disease.

Type 5 Alzheimer’s disease is traumatic, or dazed, so if you have a history of head trauma—whether from a traffic accident or a fall or even repeated minor head injuries during sports—you are at increased risk for Alzheimer’s disease.

You can see from these different types of Alzheimer’s disease we identified, and the causes of each one, that virtually all of us are at some risk for Alzheimer’s, and indeed, this is one of the reasons that it is such a common disease. With the many toxins to which we are exposed, the processed foods, the high-carbohydrate and unhealthy fat content of the SAD (standard American diet), the leaky gut so many of us have, and the lipid abnormalities (“cholesterol,” although the cholesterol itself is actually not the problem), most of us have a significant risk for Alzheimer’s disease. The good news is that nearly all of us can avoid or reverse the problem, now that we understand the contributors. To do that, we simply need to address the underlying drivers of the disease process—it’s like patching thirty-six holes in your roof—the same ones that we profile in the subtyping described above, and the earlier we do this, the easier it is to achieve success. The overall goal of treatment can be summarized as removal, resilience, and rebuilding: removal  of the exposures contributing to cognitive decline, resilience  resulting from optimal health support, and rebuilding  of the neural network.

Excerpted from THE END OF ALZHEIMER’S PROGRAM by arrangement with Avery Books, a member of Penguin Group (USA) LLC, A Penguin Random House Company. Copyright © 2020, Dale E. Bredesen



The New York Times Best Selling author of The End of Alzheimer’s lays out a specific plan to help everyone prevent and reverse cognitive decline or simply maximize brainpower.

In The End of Alzheimer’s  Dale Bredesen laid out the science behind his revolutionary new program.  This program is the first to both prevent and reverse symptoms of Alzheimer’s disease. Now he lays out the detailed program he uses with his own patients. Accessible and detailed, it can be tailored to anyone’s needs and will enhance cognitive ability at any age.

Important to realize, what we call Alzheimer’s disease is actually a protective response to a wide variety of insults to the brain.  Significantly, these can be inflammation, insulin resistance, toxins, infections, and inadequate levels of nutrients, hormones, and growth factors. First, Bredesen starts by having us figure out which of these insults we need to address.  Then, he continues by laying out a personalized lifestyle plan. The Ketoflex 12/3 Diet triggers ketosis and lets the brain restore itself with a minimum 12-hour fast. Focusing on this diet and fast, Dr. Bredesen drills down on restorative sleep, targeted supplementation, exercise, and brain training. Also, he examines the tricky question of toxic exposure and provides workarounds for many difficult problems. Finally, the takeaway is that we do not need to do the program perfectly.  However, we will see tremendous results if we can do it well enough.

This book shifts the treatment paradigm with inspiring stories from patients who have reversed cognitive decline and are now thriving.  Not only does it offer a new and effective way to enhance cognition, but also gives unprecedented hope to sufferers of this now no longer deadly disease.

What’s new and different from his first book, The End of Alzheimer’s?

  • New findings and key lessons learned over the eight years since clinical application of the ReCODE protocol began.
  • An expanded and updated list of biomarker target values and tests associated with cognition. Now known as a “cognoscopy”, this set of blood tests and a simple online cognitive assessment reveals risk for Alzheimer’s.
  • Expanded classification of the Alzheimer’s subtypes – This classification has been updated to include glycotoxic, vascular, and traumatic.
  • Introducing the KetoFLEX 12/3 Brain Food Pyramid – a pyramid optimized for brain function and prevention of cognitive decline.
  • A deep dive into dementogens, the toxic contributors to cognitive decline that we are exposed to daily. Chiefly, these chemicals and compounds include metals, organic toxins, and biotoxins. As can be seen in his book, Bredesen demonstrates how minimizing exposure, optimizing detoxification, and targeting treatment are critical for best outcomes.
  • Oral health – Your mouth is emerging as one of the most important sources for the insults associated with cognitive decline.
  • The microbiome and holobiome. Our holobiome (the sum total of microbiomes of our gut, skin, sinuses, etc.) and those that invade and infect us—are critical determinants of our cognition.  Also, these organisms living within us determine risk for cognitive decline and progression of cognitive decline.  The book features the latest information on how to optimize your microbiome.  Additionally, it includes a detailed action plan for gut health.
  • Personalized nutritional supplements. First, it is necessary to start with an examination of our biochemical goals. The book outlines what we can employ to bring about the critical changes in neurochemistry.  These changes are necessary for prevention and reversal of cognitive decline.


Final Thoughts:

First thing to remember – Dr. Bredesen’s books are written for everyone and that includes the medical community.  His books are a wealth of information, yet the material is easily understood.  In other words, you don’t need to be a doctor to follow his roadmap to better cognition!

Again, it’s important to realize that results can be seen even if the patient isn’t following their customized  program perfectly.  Dr. Bredesen discovered there are 36 or more causes of Alzheimer’s.  He uses the example of a roof with 36 holes.  Once enough of the holes in your roof are patched (or insults to your brain addressed), the damage (or ALZ symptoms) begin to halt and reverse.

Above all, just know there is a successful treatment for Alzheimer’s and dementia available now.  The Bredesen ProtocolTM has helped hundreds of people halt and reverse their cognitive decline.  It is not a cure.  Those who fall off their program notice a decline in their thought processes.  It is a treatment that must be maintained, but is so worth it!  Hold onto that hope.  Watch and listen to ALZ Survivor Stories.  Check out HOW IS THIS POSSIBLE?  Then go to the GET STARTED page.

Here’s the difference between a standard treatment and a “tailor made” customized  treatment.

Standard Treatment Customized Treatment
one-size-fits-all ALZ treatment doesn't work customized ALZ treatment works
This standard treatment includes:
 – Doctor treating you blindly
 – Pills that may only be helpful for awhile
 – Advice to put your affairs in order
 – No hope
The Bredesen ProtocolTM includes:
 – Testing to reveal your ALZ causes
 – Customized program to target causes
 – Diet & Lifestyle Strategies
 – Hope, knowing others are ALZsurvivors!

Therefore, it’s not a silver bullet, but customized  silver buckshot that’s needed to combat dementia and Alzheimer’s.  In conclusion, Dr. Bredesen’s team at Apollo Health will answer any questions you have.  If you’re ready now to reverse your cognitive decline or help a loved one get started, here is the information you need.

Contact Apollo Health:

   Phone:  800-450-0805

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abbreviation for Alzheimer’s Disease
Alzheimer’s Disease
a type of dementia and a progressive disease of the brain that slowly causes impairment in memory and cognitive function. Alzheimer’s disease happens when the brain tries to protect itself from three metabolic and toxic threats: 1 - Inflammation (from infection, diet or other causes) 2 - Decline and shortage of supportive nutrients, hormones and other brain-supporting molecules 3 - Toxic substances such as metals or biotoxins (poisons produced by microbes such as molds) The protective response causes APP (Amyloid Precursor Protein, the long molecule that protrudes from neurons) to be cut into four fragments, including amyloid-beta, that downsize the neural network and eventually destroy synapses and neurons. When the APP molecule is cut into those four pieces, it is not cut into the two pieces that nourish and maintain synapses. Alzheimer's disease is a state of the brain in which there is an imbalance between the reorganization of synapses that have outlived their usefulness (and which the brain can stand to lose - healthy destruction) and the maintenance or creation of existing and new synapses (which the brain needs to sustain old memories and form new ones, as well as perform other cognitive functions). That imbalance  comes from too many  of the synapse- and neuron-destroying quartet  of molecules snipped from APP and too few  of the synapse- and neuron-sustaining duo  of molecules snipped from APP.
abbreviation for apolipoprotein E, a gene variant (allele) which is a protein that carries lipids – i.e. fats. Carrying one ApoE4 (inherited from one parent) increases your lifetime risk of Alzheimer’s to 30 percent. Carrying two copies (from both parents) increases it to 50 to 90 percent. That compares to a risk of only about 9 percent in those who carry zero copies of this allele.
abbreviation for Amyloid Precursor Protein, the long molecule that protrudes from neurons
metabolic and genetic testing that identifies cognitive decline or what may be putting you at risk for it
umbrella term for a group of symptoms (a syndrome) without a definitive diagnosis. Dementia is a group of symptoms that affect mental cognitive tasks such as memory and reasoning. (Alzheimer’s Disease is the most common type of dementia.)
Early Alzheimer’s Disease
an early onset of Alzheimer’s Disease and uncommon form of dementia that typically affects those under the age of 65
Functional Medicine
a systems biology–based approach that focuses on identifying and addressing the root cause of disease
carrying 1 copy of the ApoE4 genetic variant
carrying 2 copies of the ApoE4 genetic variant
Integrative Medicine
healing-oriented medicine that takes account of the whole person, including all aspects of lifestyle. It emphasizes the therapeutic relationship between practitioner and patient, is informed by evidence, and makes use of all appropriate therapies.
Ketoflex 12/3
anti-Alzheimer’s diet to include at least 12 hours of fasting, with the first 3 hours of that fast starting after dinner. It is largely plant based, but flexible as it does allow for small amounts of meat or fish.
Mild Cognitive Impairment
MCT oil
an abbreviation for medium chain triglyceride (a saturated fat) which is found in coconut oil.  Alzheimer's impairs the brain's ability to use sugar.  An MCT ketogenic diet offers an alternative energy source:  ketones.  This allows brain cells to survive better, blocking a receptor in the brain that causes memory loss.
Subjective Cognitive Impairment – a precursor to MCI (Mild Cognitive Impairment)
The Bredesen ProtocolTM
treatment program developed by Dr. Dale E. Bredesen to prevent and reverse cognitive decline (also known as The ReCODE ProtocolTM)

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