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1 - Inflammation (from infection, diet or other causes
2 - Decline and shortage of supportive nutrients, hormones and other brain-supporting molecules
3 - Toxic substances such as metals or biotoxins (poisons produced by microbes such as molds)
Alzheimer's disease is a state of the brain in which there is an imbalance between the reorganization of synapses that have outlived their usefulness (and which the brain can stand to lose - healthy destruction) and the maintenance or creation of existing and new synapses (which the brain needs to sustain old memories and form new ones, as well as perform other cognitive functions). That imbalance comes from too many of the synapse- and neuron-destroying quartet of molecules snipped from APP and too few of the synapse- and neuron-sustaining duo of molecules snipped from APP.