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Dr. Bredesen:  In this new book, “The First Survivors of Alzheimer’s,” I was so excited to get these seven first-person stories from people that show what it’s like to get better from Alzheimer’s and also how each one did it.  Each person talks about what they’re doing every day to give them success.  The other part of the book is about what is the latest in terms of the Protocol itself.  What have we learned over the last few years?  How can we make this better?  Where are things going?  How can we adapt this to other neurodegenerative diseases and how can we help people who have normal cognition do quite a bit better? 

Deborah:  I couldn’t tell some people apart.  I think most people can, so that would be one of the first symptoms that I got.  There were others, but I started to get concerned that something wasn’t right.  I just didn’t know what it was.  My dad had Alzheimer’s at the time.  My grandmother had died of Alzheimer’s.  I knew it ran in the family, and I was worried that I might get it.  So, yes I was on high alert, but I didn’t think that I was actually having symptoms. 

Sally:  I knew beyond a shadow of a doubt I had the early stages of Alzheimer’s when I forgot to pick up my grandchildren to take them to school one morning after my son had just called me the night before. 

Frank:  The result was trying to run a business for four years with dementia, a business that had been really successful for decades.  I lost almost our entire life savings. 

Marcy:  Despite a pile of parking tickets, I could not remember to put money in the meter.  Despite having tick-borne diseases, I could not remember to put on the right things when I went outside.  Despite many skin cancer scares, I’d forget every time.  And worse, when I’d read a book, the very next day I could read the page over unless I underlined it.  All of it was falling through my mind.

Deborah:  I dove in with my full heart with hope that it might stave it off.  And if I could stave off what my dad went through even by a few years, I knew it would be worth it.  That was sort of my mindset going in.  And then as I started to improve, I just started to jump up and down.  I wanted to like scream it out because there must be others like me out there. 

Sally:  When I have a pilates or a lunch scheduled with a friend,  I remember it.  When I go from one end of the house to the other to find something, I get there and remember what I went for.  And most of all, I now am very reliable in picking up my granddaughter and on time. 

Marcy:  It works.  And it has no side effects and each thing is good for your overall health. 

Dr. Bredesen:  We want to combine basically seven things.  We want to combine diet, exercise, sleep, stress reduction, brain training, detoxification for those who need it, and specific supplements.  There are absolutely pills that can be very helpful.  Some of them are supplements, others are drugs, and some hormones depending on your own status. 

Sally:  Research was my answer and the national trial didn’t work.  But then Dr. Bredesen’s research worked for me and continues to work for me.

Deborah:  Things like recognizing faces was one of the first symptoms to improve.  For the first time at about the five-month mark of being on the Protocol, I could recognize people that I had been exercising with in a class every day. 

Dr. Bredesen:  That’s what really gets me up in the morning and that’s what really gets me excited about this.  Can we now do this better and better for more and more people?  And so I was just so excited about having the people write their stories and having people be able to read them and say, “Hey wait a minute.  You know, there is some hope  for me.”

NOTE:  Read more about The First Survivors of Alzheimer’s” by Dale E. Bredesen, MD.

The First Survivors of Alzheimer's (book 2021)
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Glossary

ALZ
abbreviation for Alzheimer’s Disease
Alzheimer’s Disease
a type of dementia and a progressive disease of the brain that slowly causes impairment in memory and cognitive function. Alzheimer’s disease happens when the brain tries to protect itself from three metabolic and toxic threats: 1 - Inflammation (from infection, diet or other causes) 2 - Decline and shortage of supportive nutrients, hormones and other brain-supporting molecules 3 - Toxic substances such as metals or biotoxins (poisons produced by microbes such as molds) The protective response causes APP (Amyloid Precursor Protein, the long molecule that protrudes from neurons) to be cut into four fragments, including amyloid-beta, that downsize the neural network and eventually destroy synapses and neurons. When the APP molecule is cut into those four pieces, it is not cut into the two pieces that nourish and maintain synapses. Alzheimer's disease is a state of the brain in which there is an imbalance between the reorganization of synapses that have outlived their usefulness (and which the brain can stand to lose - healthy destruction) and the maintenance or creation of existing and new synapses (which the brain needs to sustain old memories and form new ones, as well as perform other cognitive functions). That imbalance  comes from too many  of the synapse- and neuron-destroying quartet  of molecules snipped from APP and too few  of the synapse- and neuron-sustaining duo  of molecules snipped from APP.
ApoE4
abbreviation for apolipoprotein E, a gene variant (allele) which is a protein that carries lipids – i.e. fats. Carrying one ApoE4 (inherited from one parent) increases your lifetime risk of Alzheimer’s to 30 percent. Carrying two copies (from both parents) increases it to 50 to 90 percent. That compares to a risk of only about 9 percent in those who carry zero copies of this allele.
APP
abbreviation for Amyloid Precursor Protein, the long molecule that protrudes from neurons
CognoscopyTM
metabolic and genetic testing that identifies cognitive decline or what may be putting you at risk for it
Dementia
umbrella term for a group of symptoms (a syndrome) without a definitive diagnosis. Dementia is a group of symptoms that affect mental cognitive tasks such as memory and reasoning. (Alzheimer’s Disease is the most common type of dementia.)
Early Alzheimer’s Disease
an early onset of Alzheimer’s Disease and uncommon form of dementia that typically affects those under the age of 65
Functional Medicine
a systems biology–based approach that focuses on identifying and addressing the root cause of disease
Heterozygous
carrying 1 copy of the ApoE4 genetic variant
Homozygous
carrying 2 copies of the ApoE4 genetic variant
Integrative Medicine
healing-oriented medicine that takes account of the whole person, including all aspects of lifestyle. It emphasizes the therapeutic relationship between practitioner and patient, is informed by evidence, and makes use of all appropriate therapies.
Ketoflex 12/3
anti-Alzheimer’s diet to include at least 12 hours of fasting, with the first 3 hours of that fast starting after dinner. It is largely plant based, but flexible as it does allow for small amounts of meat or fish.
MCI
Mild Cognitive Impairment
MCT oil
an abbreviation for medium chain triglyceride (a saturated fat) which is found in coconut oil.  Alzheimer's impairs the brain's ability to use sugar.  An MCT ketogenic diet offers an alternative energy source:  ketones.  This allows brain cells to survive better, blocking a receptor in the brain that causes memory loss.
SCI
Subjective Cognitive Impairment – a precursor to MCI (Mild Cognitive Impairment)
The Bredesen ProtocolTM
treatment program developed by Dr. Dale E. Bredesen to prevent and reverse cognitive decline (also known as The ReCODE ProtocolTM)

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