ALZ Survivor Stories, ApoE4, Diet & Lifestyle, Dr. Dale E. Bredesen, The Bredesen Protocol

ALZ Survivor, Francis McNear, Shares the Story of His Recovery

March 12, 2019
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Francis states, “Thanks to a recent breakthrough in dementia studies and treatment, I am currently recovering from early onset Alzheimer’s. That is correct. I am one of several thousand people in the United States following the recently developed Bredesen Protocol and, as a result, my memory and my life have been restored to order. In this book, I will take you on my journey and will tell you about the Bredesen Protocol that saved my life.  I also provide helpful information for caregivers and outline the different kinds of dementia. I believe that, once you have read this book, you will feel empowered, whether you are facing dementia yourself or are caring for someone who is. You are not helpless.  You are not alone.  And, there is hope.  I’m living proof of this.”

In 2009, Francis began having serious problems with his memory. It took three years before he was diagnosed, and he wouldn’t admit to himself or anyone else that his mind was slipping. He was afraid, but more than that, he believed that even if he had dementia, there was nothing that could be done. He thought dementia was irreversible and terminal. Now he knows he was wrong.

“Defeating Dementia … is a critically important account that should be read by the millions in the early stages of dementia, their caregivers, the many at risk for dementia, and the families searching for the very hope that McNear provides.” Dale E. Bredesen, M.D.

You can find more information on Francis’ Defeating Dementia Facebook page.

Order this book here.
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Glossary


ALZ

abbreviation for Alzheimer’s Disease

Alzheimer’s Disease

a type of dementia and a progressive disease of the brain that slowly causes impairment in memory and cognitive function. Alzheimer’s disease happens when the brain tries to protect itself from three metabolic and toxic threats:

1 - Inflammation (from infection, diet or other causes)

2 - Decline and shortage of supportive nutrients, hormones and other brain-supporting molecules

3 - Toxic substances such as metals or biotoxins (poisons produced by microbes such as molds)


The protective response causes APP (Amyloid Precursor Protein, the long molecule that protrudes from neurons) to be cut into four fragments, including amyloid-beta, that downsize the neural network and eventually destroy synapses and neurons. When the APP molecule is cut into those four pieces, it is not cut into the two pieces that nourish and maintain synapses.

Alzheimer's disease is a state of the brain in which there is an imbalance between the reorganization of synapses that have outlived their usefulness (and which the brain can stand to lose - healthy destruction) and the maintenance or creation of existing and new synapses (which the brain needs to sustain old memories and form new ones, as well as perform other cognitive functions). That imbalance  comes from too many  of the synapse- and neuron-destroying quartet  of molecules snipped from APP and too few  of the synapse- and neuron-sustaining duo  of molecules snipped from APP.


ApoE4

abbreviation for apolipoprotein E, a gene variant (allele) which is a protein that carries lipids – i.e. fats. Carrying one ApoE4 (inherited from one parent) increases your lifetime risk of Alzheimer’s to 30 percent. Carrying two copies (from both parents) increases it to 50 to 90 percent. That compares to a risk of only about 9 percent in those who carry zero copies of this allele.

APP

abbreviation for Amyloid Precursor Protein, the long molecule that protrudes from neurons


Cognoscopy

metabolic and genetic testing that identifies cognitive decline or what may be putting you at risk for it

Dementia

umbrella term for a group of symptoms (a syndrome) without a definitive diagnosis. Dementia is a group of symptoms that affect mental cognitive tasks such as memory and reasoning. (Alzheimer’s Disease is the most common type of dementia.)

Early Alzheimer’s Disease

an early onset of Alzheimer’s Disease and uncommon form of dementia that typically affects those under the age of 65

Functional Medicine

a systems biology–based approach that focuses on identifying and addressing the root cause of disease

Heterozygous

carrying 1 copy of the ApoE4 genetic variant

Homozygous

carrying 2 copies of the ApoE4 genetic variant

Integrative Medicine

healing-oriented medicine that takes account of the whole person, including all aspects of lifestyle. It emphasizes the therapeutic relationship between practitioner and patient, is informed by evidence, and makes use of all appropriate therapies.

Ketoflex 12/3

anti-Alzheimer’s diet to include at least 12 hours of fasting, with the first 3 hours of that fast starting after dinner. It is largely plant based, but flexible as it does allow for small amounts of meat or fish.

MCI

Mild Cognitive Impairment

MCT oil

an abbreviation for medium chain triglyceride (a saturated fat) which is found in coconut oil.  Alzheimer's impairs the brain's ability to use sugar.  An MCT ketogenic diet offers an alternative energy source:  ketones.  This allows brain cells to survive better, blocking a receptor in the brain that causes memory loss.

SCI

Subjective Cognitive Impairment – a precursor to MCI (Mild Cognitive Impairment)

The Bredesen Protocol

treatment program developed by Dr. Dale E. Bredesen to prevent and reverse cognitive decline (also known as The ReCODE ProtocolTM)